Shalev Itzkovitz

Our lab applies tools from Systems Biology to study the design principles of mammalian tissues. Mammalian tissues are composed of heterogeneous cells, interacting in highly structured microenvironments to achieve physiologic goals. We seek to understand how the structure of tissues and their single-cell gene expression patterns serve to achieve these goals and how these intercellular interactions are perturbed in disease. We apply an interdisciplinary approach, combining novel measurement techniques of single cells in intact tissues with mathematical models.