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Noam Stern-Ginossar

Viruses are completely reliant on the host cell machinery and have evolved many mechanisms to hijack it for their propagation. At the same time our cells have developed defense mechanisms to cope with infections. Our research aims to elucidate the complex cellular changes that occur during these virus-cell encounters.

We employ a deep-sequencing technique termed ribosome profiling that allows a comprehensive view of translation events. The robustness, scale, and accuracy of this method provide a unique opportunity to follow the molecular events underlying infection with unprecedented depth. We aim to use this novel resolution to unfold the processes that occur during viral infection and to reveal fundamental cellular principles.