About I-CORE

Chromatin & RNA Gene Regulation I-CORE

Regulation of gene expression is one of the core questions in biology - how does each cell controls which genes are expressed and to what extent. Indeed, regulatory mechanisms are crucial for proper functioning of the cell, for making critical developmental decisions and for adequetely responding to external or internal cues. Conversely, impairment of these control mechanisms is causative of many diseases, including most cancer types.

Scientific breakthroughs during the last decade challenge the simplistic dogma that “DNA makes RNA make protein” and reveal additional mechanisms of gene expression regulation involving many non-canonical interactions between RNA, chromatin and the transcription, splicing and translation machineries. And yet, despite these exciting advances, our understanding of the organization and interconnection between those heterogeneous regulatory layers is still limited, and so is our current ability to define how perturbations of such regulatory elements could underlie the pathogenesis of human diseases.

In our Israeli Center of Excellence (I-CORE) we employ systematic approaches, including high-throughput quantitative techniques and advanced computational models in order to decipher these multiple layers of regulation in a wide range of physiological models.
We have assembled a team of multidsiplinary scientists from the Hebrew University, Weizmann Institute, Bar-Ilan University, Sheba Medical Center and the Technion, that study these regulatory processes at different levels: the interaction of chromatin and epigenetic marks with transcription; the role of non-coding RNAs in regulating RNA editing, maturation, degradation and translation; and the feedback effect of non-coding RNA on transcription and chromatin. In addition, our team spans a range of biological systems from microorganisms, through development model organisms, to mammalian systems of physiological importance such as stem cells, immune system and brain.

​This effort will hopefully bridge the gap between basic regulatory mechanisms and their physiological consequences in development, differentiation, health and disease.

 

Chromatin & RNA Gene Regulation I-CORE